This Standard applies to Class II (laminar flow) biosafety cabinetry designed to minimize hazards inherent in work with agents assigned to biosafety levels 1, 2, 3, or 4. It also defines the tests that shall be passed by such cabinetry to meet this Standard. This Standard includes basic requirements for the design, construction, and performance of biosafety cabinets that are intended to provide personnel, product, and environmental protection; reliable operation; durability and structural stability; cleanability; limitations on noise level; illumination; vibration; and motor/blower performance.

Minimum requirements

Cabinets qualifying under this Standard shall have passed all of the designated tests. Units with component parts covered under existing NSF standards or criteria shall conform to those applicable requirements.

Variations in design and construction

Cabinetry varying in design, construction, or installation of accessory equipment may qualify under this Standard, if appropriate tests and investigations indicate that the equipment is durable and reliable, can be cleaned and decontaminated, and performs in conformance to this Standard. Such equipment shall meet the requirements for materials and finishes in this Standard.

Major modifications require appropriate tests for conformance. Major modifications include, but are not limited to, changes in the following: location or capacity or quantity or all three of blower/motor(s); size or design or both of air plenums; position of High Efficiency Particulate Air (HEPA) filters; position or redesign of work surface; work area intake and exhaust air grilles; window placement or design; access opening size; location and size of exhaust port; and built-in accessory equipment (centrifuges, ultraviolet lighting, supports for intravenous drug container, arm rests, etc.). Relocation of utility service equipment (electrical outlets, petcocks, etc.) is not considered a major modification if other provisions of this Standard are not compromised.

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• API SPEC 5L : Specification for Line Pipe-FORTY-FIFTH EDITION; EFFECTIVE DATE: JULY 1, 2013
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